Asymptomatic COVID-19 Adult Outpatients identified as Significant Viable SARS-CoV-2 Shedders - Laboratoire de Virologie Médicale et Moléculaire - EA 4684
Article Dans Une Revue Scientific Reports Année : 2021

Asymptomatic COVID-19 Adult Outpatients identified as Significant Viable SARS-CoV-2 Shedders

Résumé

Differential kinetics of RNA loads and infectious viral levels in the upper respiratory tract between asymptomatic and symptomatic SARS-CoV-2 infected adult outpatients remain unclear limiting recommendations that may guide clinical management, infection control measures and occupational health decisions. In the present investigation, 496 (2.8%) of 17,911 French adult outpatients were positive for an upper respiratory tract SARS-CoV-2 RNA detection by a quantitative RT-PCR assay, of which 180 (36.3%) were COVID-19 asymptomatic. Of these adult asymptomatic viral shedders, 75% had mean to high RNA viral loads (Ct values < 30) which median value was significantly higher than that observed in symptomatic subjects ( P = 0.029), and 50.6% were positive by cell culture assays of their upper respiratory tract specimens. Our findings indicate that COVID-19 asymptomatic adult outpatients are significant viable SARS-CoV-2 shedders in their upper respiratory tract playing a major potential role as SARS-CoV-2 transmitters in various epidemiological transmission chains, promoting COVID-19 resurgence in populations.

Domaines

Virologie
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Dates et versions

hal-03409156 , version 1 (29-10-2021)

Identifiants

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Marie Glenet, Anne-Laure Lebreil, Laetitia Heng, Yohan N’guyen, Ittah Meyer, et al.. Asymptomatic COVID-19 Adult Outpatients identified as Significant Viable SARS-CoV-2 Shedders. Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-00142-8⟩. ⟨hal-03409156⟩

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