A microstrip resonator based sensor for GHz characterization of in vitro cell culture - ETIS, équipe ASTRE
Conference Papers Year : 2018

A microstrip resonator based sensor for GHz characterization of in vitro cell culture

Abstract

This contribution describes a sensor for GHz characterization of in vitro cell culture, that overcomes the limitation in high frequency of classical bio-impedance spectroscopy. The sensor we developed enables to monitor a thin layer of approximatively 30µm of cells in their liquid culture medium for a relative permittivity in the range of 5 to 55. Here, we demonstrate the measurement principle using a Finite Element model, which has been validated with experimental response. Our sensor has a minimal sensitivity of 0.3M Hz. We also used a multiphysics model to demonstrate that this technology does not affect tissue safety for input power level compatible with a sufficient measurement signal on noise ratio. This technology will be used in experiments aiming at the exploration of biomarkers for post-implantation inflammatory reactions of active devices.

Domains

Electronics
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Dates and versions

hal-01985834 , version 1 (18-01-2019)

Identifiers

  • HAL Id : hal-01985834 , version 1

Cite

Florian Kölbl, N Boulboul, M Commereuc, E Bourdel. A microstrip resonator based sensor for GHz characterization of in vitro cell culture. 12th International Conference On Sensing Technology (ICST 2018), Dec 2018, Limerick, Ireland. ⟨hal-01985834⟩
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