European industrial production has been centralised in large installations located far from the places of consumption. This relocation can be explained by the search for economies of scale and the avoidance of nuisance associated with certain activities, at a time when the clean technologies that exist today were not available. It has also led to a hyper-specialisation of factories, with the need for large volumes of the same category of products in a given location. Researches exist about the identification of possible urban plant locations and their potential negative and positive impacts according to multicriteria models based on quantitative or qualitative data. Although they focus on installations producing only one type of product, it may be possible to develop multipurpose urban production sites that would be capable of designing and manufacturing a multitude of different products able to satisfy a range of needs, while sourcing within an optimised perimeter and strengthening the local resilience. This article presents a methodological proposal that could help develop a model of multipurpose urban factory based on identification of a need, definition of the products which can fulfill the need, and the means to manufacture them. After a literature review and the description of the method, a case study about hygiene products is presented. Then, an environmental screening is used to verify the relevance of the approach. Finally, the method and the case study are discussed, and perspective of further research are proposed.