An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase
Abstract
A combinatorial approach using a One-Bead-One-Compound method and a screening based on an SOD-activity assay was set up for the discovery of an efficient peptidyl copper complex. The complex exhibited good stability constants, suitable redox potentials and excellent intrinsic activity. This complex was further assayed in cells for its antioxidant properties and showed beneficial effect when cells were submitted to oxidative stress.
Origin : Files produced by the author(s)
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