Baseline characteristics, management, and predictors of early mortality in cardiogenic shock: insights from the FRENSHOCK registry - Centre de Recherche Supply chain Management Access content directly
Journal Articles ESC Heart Failure Year : 2022

Baseline characteristics, management, and predictors of early mortality in cardiogenic shock: insights from the FRENSHOCK registry

1 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
2 UPS/Inserm U1297 - I2MC - Institut des Maladies Métaboliques et Casdiovasculaires
3 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
4 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
5 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
6 Université de Lille
7 Institut Pasteur de Lille
8 RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
9 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
10 MARS cardio - Mediterranean Association for Research and Studies in Cardiology
11 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
12 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
13 Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy]
14 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
15 HEGP - Hôpital Européen Georges Pompidou [APHP]
16 FACT - Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials
17 Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion]
18 Hôpital privé de Parly 2 - Ramsay Santé [Le Chesnay-Rocquencourt]
19 IMRB - Institut Mondor de Recherche Biomédicale
20 Hôpital Henri Mondor
21 BB - Biomatériaux et Bioingénierie
22 Hôpital de Hautepierre [Strasbourg]
23 MÉDIATIONS - Sciences des lieux, sciences des liens
24 Hôpital Cochin [AP-HP]
25 CHIAP - Centre Hospitalier d'Aix en Provence [Aix-en-Provence]
26 TIMONE - Hôpital de la Timone [CHU - APHM]
27 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
28 Institut Coeur Poumon [CHU Lille]
29 CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
30 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
31 Hôpital de la Croix-Rousse [CHU - HCL]
32 LRB - Radiopharmaceutiques biocliniques
33 Département de cardiologie [CHU de Grenoble]
34 CH de Saint-Malo [Broussais]
35 COVID-Mucor study group
36 Nouvel Hôpital Civil de Strasbourg
37 CHU Clermont-Ferrand
38 UCA - Université Clermont Auvergne
39 Hôpital Lariboisière-Fernand-Widal [APHP]
40 HCL - Hospices Civils de Lyon
41 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
42 UM - Université de Montpellier
43 CRCTB - Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux]

Abstract

Abstract Aims Published data on cardiogenic shock (CS) are scarce and are mostly focused on small registries of selected populations. The aim of this study was to examine the current CS picture and define the independent correlates of 30 day mortality in a large non‐selected cohort. Methods and results FRENSHOCK is a prospective multicentre observational survey conducted in metropolitan French intensive care units and intensive cardiac care units between April and October 2016. There were 772 patients enrolled (mean age 65.7 ± 14.9 years; 71.5% male). Of these patients, 280 (36.3%) had ischaemic CS. Organ replacement therapies (respiratory support, circulatory support or renal replacement therapy) were used in 58.3% of patients. Mortality at 30 days was 26.0% in the overall population (16.7% to 48.0% depending on the main cause and first place of admission). Multivariate analysis showed that six independent factors were associated with a higher 30 day mortality: age [per year, odds ratio (OR) 1.06, 95% confidence interval (CI): 1.04–1.08], diuretics (OR 1.74, 95% CI: 1.05–2.88), circulatory support (OR 1.92, 95% CI: 1.12–3.29), left ventricular ejection fraction <30% (OR 2.15, 95% CI: 1.40–3.29), norepinephrine (OR 2.55, 95% CI: 1.69–3.84), and renal replacement therapy (OR 2.72, 95% CI: 1.65–4‐49). Conclusions Non‐ischaemic CS accounted for more than 60% of all cases of CS. CS is still associated with significant but variable short‐term mortality according to the cause and first place of admission, despite frequent use of haemodynamic support, and organ replacement therapies.
Fichier principal
Vignette du fichier
2022 Delmas et al., Baseline characteristics.pdf (737.93 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-04277804 , version 1 (29-11-2023)

Identifiers

Cite

Clement Delmas, François Roubille, Nicolas Lamblin, Laurent Bonello, Guillaume Leurent, et al.. Baseline characteristics, management, and predictors of early mortality in cardiogenic shock: insights from the FRENSHOCK registry. ESC Heart Failure, 2022, 9 (1), pp.408-419. ⟨10.1002/ehf2.13734⟩. ⟨hal-04277804⟩
84 View
12 Download

Altmetric

Share

Gmail Facebook X LinkedIn More