LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy
Résumé
Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes of multiple alphaviruses to understand their ability to infect a wide range of hosts. We further discuss the challenges associated with the development of broad-spectrum treatment strategies against a diverse range of alphaviruses.
Domaines
Sciences du Vivant [q-bio]| Origine | Publication financée par une institution |
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