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Agreement between two non-contact specular microscopes: Topcon SP2000P versus Rhine-Tec

Abstract : Endothelial cell density (ECD) assessment with the noncontact Topcon SP2000P specular microscope is known to be reliable when the automated mode is followed by manual corrections (touched-up mode). We compared its agreement with Rhine-Tec, a new noncontact specular microscope, in 270 eyes of 160 patients, by comparing the ECD measured in the automated and touched-up modes with that of Topcon touched-up. Good agreement existed between either touched-up modes with a mean difference of only 2 cells/mm2 95% CI (−27; 23) whereas agreement with the Rhine-Tec automated mode was poor with an overestimation by a mean of 226 cells/mm2 95% CI (172; 281). Background The Topcon SP2000P non-contact specular microscope (Topcon, Tokyo, Japan) is widely used to measure corneal endothelial cell density (ECD). It uses a cell contour recognition algorithm based on contrast differences, and ECD derived from an automated delineation of cell boundaries with manual correction of inaccurately drawn cells (“touched-up” mode) has been validated.1,2 A new commercially available non-contact specular microscope Rhine-Tec (Rhine-Tec, Krefeld, Germany) determines ECD by a cell-centre method ...
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Submitted on : Tuesday, January 12, 2010 - 10:06:47 AM
Last modification on : Wednesday, June 24, 2020 - 4:18:36 PM

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Gilles Thuret, Nilanjana Deb-Joardar, Zhao Hui, Yann Gavet, Frédéric Nguyen, et al.. Agreement between two non-contact specular microscopes: Topcon SP2000P versus Rhine-Tec. British Journal of Ophthalmology, BMJ Publishing Group, 2007, 91 (7), pp.979-980. ⟨10.1136/bjo.2006.099374⟩. ⟨emse-00446115⟩



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