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Biosensor for on-line monitoring of penicillin during its production by fermentation

Abstract : An enzyme sensor has been developed for the on-line monitoring of penicillin V during its production by fermentation. The enzyme is crosslinked as a very fine film to the sensitive end of a pH transducer, using the spraying method. The biosensor is incorporated in a flow injection analysis (FIA) system within a home-made stirred flow detection cell. Penicillin V in fermentation broth is detected during the whole fermentation process and the results are compared with the HPLC method. On-line measurements are achieved through the automation of the FIA system.
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Submitted on : Tuesday, August 30, 2011 - 3:17:28 PM
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  • HAL Id : emse-00565820, version 1

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Helmut Meier, Canh Tran Minh. Biosensor for on-line monitoring of penicillin during its production by fermentation. Bimbenet, J.J. ; Dumoulin, E. ; Trystram, G. Automatic control of food and biological processes Proceedings of the ACoFoP III Symposium, Paris, France, 25-26 October, 1994, Elsevier 0-444-81959-2, pp.83-88, 1994, Developments in food science, ISSN 0167-4501 ; N°36. ⟨emse-00565820⟩

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