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Journal Articles Powder Technology Year : 1999

Modelling to understand porosity and specific surface area changes during tabletting

Abstract

This study presents the porosity and corresponding specific surface area evolution of pharmaceutical tablets vs. compaction pressure. A model based on quasi-chemical treatments and population balances is proposed to understand these evolutions. The main phenomena, namely fragmentation and plastic deformation, which occur in pharmaceutical powder compaction, are taken into account to explain the conjugate evolution of these macroscopic properties. These phenomena are quantified through the different parameters of the model. Experimental results on tablettose, saccharose and ketoprofen tablets show a fair agreement with theoretical results, and allow us to classify the fragmentation and the plastic deformation abilities of the products.

Dates and versions

emse-00609954 , version 1 (20-07-2011)

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Jean-Claude Masteau, Gérard Thomas. Modelling to understand porosity and specific surface area changes during tabletting. Powder Technology, 1999, 101 (3), pp.240-248. ⟨10.1016/S0032-5910(98)00173-9⟩. ⟨emse-00609954⟩
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