The architecture of the medPRO framework has been designed from the analysis of two health care departments: the pharmacy department and the operating theatre. We were able to build a comprehensive framework for these departments, allowing us to model different organisations observed in several hospitals. To do that, we (i) listed and formalized the needs of system actors and (ii) proposed personalized views for each category of the working staff. We focused on communication, simplicity and rapidity. Furthermore, models have to be simulated in order to get results quickly. This framework consists of a list of generic resources and activities description, and a handbook describing the base system. The UML (Unified Modelling Language) has been chosen to model these systems. Several points Technical Presentations of view have been selected: process (activity diagrams), resource (state charts) and organisation (class diagrams). The process view represents the patient flow in a specific medical department: only activities related to the patient are modelled. The resource view represents the behaviour of each resource (human or material), including tasks that does not appear in the process view. Finally, the organization view represents a global view of the system: number, specialities and scope of resources, relations between them, etc. A synchronisation system is used to link these views, which constitute the physical sub-system. From this point, we developed a formalized framework and a simulation algorithm, namely a complete architecture. Although our modelling and simulation tool is still under construction, we were able to model the operating theatre process with our framework on one hand, and with traditional modelling tools on the other hand. This way, we were able to evaluate the accuracy of medPRO. A control system will also be developed in order to manage (i) disturbances during the simulation process, (ii) the settings of the simulation model, (iii) the decision process. This control system will also be useful to manage interactions between actors in order to change dynamically the system organization (scheduling of tasks, preemption, etc.). Holonic systems may be a relevant tool to complete our model.