In vitro toxicity of carbon nanotubes, nano-graphite and carbon black, similar impacts of acid functionalization

Abstract : Carbon nanotubes (CNT) and nano-graphite (NG) are graphene-based nanomaterials which share exceptional physicochemical properties, but whose health impacts are unfortunately still not well understood. On the other hand, carbon black (CB) is a conventional and widely studied material. The comparison of these three carbon-based nanomaterials is thus of great interest to improve our understanding of their toxicity. An acid functionalization was carried out on CNT, NG and CB so that, after a thorough characterization, their impacts on RAW 264.7 macrophages could be compared for a similar surface chemistry (15 to 120 μg·mL− 1 nanomaterials, 90-min to 24-h contact). Functionalized nanomaterials triggered a weak cytotoxicity similar to the pristine nanomaterials. Acid functionalization increased the pro-inflammatory response except for CB which did not trigger any TNF-α production before or after functionalization, and seemed to strongly decrease the oxidative stress. The toxicological impact of acid functionalization appeared thus to follow a similar trend whatever the carbon-based nanomaterial. At equivalent dose expressed in surface and equivalent surface chemistry, the toxicological responses from murine macrophages to NG were higher than for CNT and CB. It seemed to correspond to the hypothesis of a platelet and fiber paradigm.
Liste complète des métadonnées

Littérature citée [48 références]  Voir  Masquer  Télécharger

https://hal-emse.ccsd.cnrs.fr/emse-01212432
Contributeur : Fatima Lillouch <>
Soumis le : lundi 16 novembre 2015 - 10:12:51
Dernière modification le : jeudi 11 janvier 2018 - 06:23:44
Document(s) archivé(s) le : vendredi 28 avril 2017 - 14:45:30

Fichier

Figarol_Pourchez Toxicology in...
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Agathe Figarol, Jérémie Pourchez, Delphine Boudard, Valérie Forest, Céline Akono, et al.. In vitro toxicity of carbon nanotubes, nano-graphite and carbon black, similar impacts of acid functionalization. Toxicology in Vitro, Elsevier, 2015, 30 (1 Part B), pp.476-485. 〈http://www.sciencedirect.com/science/article/pii/S0887233315002271〉. 〈10.1016/j.tiv.2015.09.014〉. 〈emse-01212432〉

Partager

Métriques

Consultations de la notice

119

Téléchargements de fichiers

144