The thermal stability and temperature dependent hardness of ultrafine-grained Cu-alloys CuSn5 and CuZn5 after high pressure torsion are investigated using the high temperature scanning indentation (HTSI) method. Fast indentations are carried out during thermal cycling of the samples (heating-holding-cooling) to measure hardness and strain rate sensitivity as a function of temperature and time. The microstructures after each thermal cycle are investigated to characterize the coarsening behaviour of both alloys. Results show that the thermal stability of the tested alloys can be expressed in terms of several temperature regimes: A fully stable regime, a transient regime in which growth of individual grains occurs, and finally a regime in which the microstructure is fully coarsened. The onset of grain growth is accompanied by high strain rate sensitivity on the order of 0.2–0.3. Furthermore, the obtained hardness and strain rate sensitivity values are in good agreement with continuous stiffness measurement (CSM) and strain rate jump (SRJ) experiments. This highlights the applicability of the HTSI method to the characterization of the thermomechanical properties of ultrafine-grained alloys.