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Development of innovative pH sensor to evaluate phagocytosis of nanoparticles

Abstract : Inhaled nanoparticles (NP) exhibit variable toxicity levels which mainly depend on their physicochemical characteristics (size, morphology, crystallinity, chemical surface composition...). Biological effects monitoring thanks to usual tests (ROS, TNFα, LDH) are performed on alveolar macrophages collected from the respiratory system. In this frame, evaluation of NP uptake by macrophages appears as complementary data useful for NP toxicity assessment. The aim of this work deals with the development of pH sensible NP allowing the quantification of NP phagocytosed by macrophages, specially the step of fusion between phagosomes and lysosomes.
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Submitted on : Wednesday, March 30, 2011 - 9:47:20 AM
Last modification on : Wednesday, August 5, 2020 - 3:41:37 AM
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  • HAL Id : emse-00581050, version 1


Lara Leclerc, Delphine Boudard, Jérémie Pourchez, Sabine Palle, Philippe Grosseau, et al.. Development of innovative pH sensor to evaluate phagocytosis of nanoparticles. Bulletin du Cancer, John Libbey Eurotext, 2010, 97, pp.S15-S16. ⟨emse-00581050⟩



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