In this paper, we present a decision support tool (DSS) for preliminary design of transfer machines with rotary or mobile tables. In these transfer machines, the machining operations are executed on working positions equipped by standard multi-spindle heads. A part is sequentially machined on m working positions and is moved from one position to the next using a rotary or a mobile table. The operations are grouped into blocks, where the operations of the same block are simultaneously performed by one multi-spindle head. At the preliminary design stage, the goal is to select the number of working positions and to decide which spindle heads will be installed minimizing the machine cost while respecting a given production rate. The paper presents the overall approach and depicts mathematical and decision-support methods developed and implemented in a software for the optimization of preliminary design (or reconfiguration) of such machining systems.