Product-Service Systems are increasingly emerging in response to market volatility and more demanding customer requirements. Their development process, however, is not as straightforward as for traditional physical goods. For instance, the configuration of a Product-Service System entails taking several factors into account, such as the points of view of the different actors in the value network. This paper proposes a methodological framework supported by modelling and simulation to evaluate the performance of different configurations of the value network, referred to as scenarios, and the impact of different input parameters within these scenarios. The proposed approach is illustrated by a case study which highlights the main drivers of a new innovative sector for sludge treatment.