This chapter presents four contrasted and near-caricatured scenarios of retail location and distribution, and compares them on the bases of both road occupancy rates and greenhouse gas emissions. Two main families of scenarios are defined: retailing land-use scenarios, based on the location of the different retailing activities of a city; and end-consumer delivery organizational scenarios, based on the definition of new services to deliver end-consumers, at home or to reception points. Those scenarios are simulated using an integrated approach combining inter-establishment goods transport flows, shopping trips, and end-consumer deliveries. The assessment approach is able to show the relation between several aspects of retailing deployment (mainly store location, catchment area's supply, and urban retailing planning policies) and both upstream distribution of goods to retailers and downstream usage of private vehicles for shopping. Although scenarios are extreme and contrasted, they are able to identify the limits and forces of the different retailing strategies in urban zones.