Determination of 9-hydroxyellipticine by redox colorimetry

Pascal Formisyn 1, 2 Félix Pautet 3 Canh Tran Minh 2, 1, 4, 5 Jacques Bourgois 2, 1
1 LB-ENSMSE - Laboratoire de Biotechnologie
2 Mines Saint-Étienne MSE - École des Mines de Saint-Étienne
3 LCO - Laboratoire de Chimie Organique
4 SPIN-ENSMSE - Centre Sciences des Processus Industriels et Naturels
5 P2MC-ENSMSE - Département Poudres et Matériaux Multi-Composants
Abstract : The chemical reactions involved in the decomposition of 9-hydroxyellipticine (9-OH-E), an anticancer agent, in polar solvents is explained. The reactions, which involve the formation of 9-oxo-ellipticine and the addition of a nucleophilic acid on the C10 site of the heterocyclic system, have been used to measure 9-OH-E quantitatively by colorimetry in solution and by reflection on paper surfaces. A method for the stabilization of 9-OH-E in polar solvents is proposed.
Keywords : 9-Hydroxyellipticine mechanism of instability qualitative and quantitative analysis thin-layer chromatography colour measurement stabilization
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Journal articles
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https://hal-emse.ccsd.cnrs.fr/emse-00566875
Contributor : Andrée-Aimée Toucas <>
Submitted on : Thursday, February 17, 2011 - 11:56:07 AM
Last modification on : Thursday, November 21, 2019 - 1:53:54 AM

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Pascal Formisyn, Félix Pautet, Canh Tran Minh, Jacques Bourgois. Determination of 9-hydroxyellipticine by redox colorimetry. Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 1992, 10 (6), pp.427-436. ⟨10.1016/0731-7085(92)80061-Q⟩. ⟨emse-00566875⟩

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