Determination of 9-hydroxyellipticine by redox colorimetry - Mines Saint-Étienne Access content directly
Journal Articles Journal of Pharmaceutical and Biomedical Analysis Year : 1992

Determination of 9-hydroxyellipticine by redox colorimetry

Abstract

The chemical reactions involved in the decomposition of 9-hydroxyellipticine (9-OH-E), an anticancer agent, in polar solvents is explained. The reactions, which involve the formation of 9-oxo-ellipticine and the addition of a nucleophilic acid on the C10 site of the heterocyclic system, have been used to measure 9-OH-E quantitatively by colorimetry in solution and by reflection on paper surfaces. A method for the stabilization of 9-OH-E in polar solvents is proposed.

Dates and versions

emse-00566875 , version 1 (17-02-2011)

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Pascal Formisyn, Félix Pautet, Canh Tran Minh, Jacques Bourgois. Determination of 9-hydroxyellipticine by redox colorimetry. Journal of Pharmaceutical and Biomedical Analysis, 1992, 10 (6), pp.427-436. ⟨10.1016/0731-7085(92)80061-Q⟩. ⟨emse-00566875⟩
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