Determination of 9-hydroxyellipticine by redox colorimetry

Abstract : The chemical reactions involved in the decomposition of 9-hydroxyellipticine (9-OH-E), an anticancer agent, in polar solvents is explained. The reactions, which involve the formation of 9-oxo-ellipticine and the addition of a nucleophilic acid on the C10 site of the heterocyclic system, have been used to measure 9-OH-E quantitatively by colorimetry in solution and by reflection on paper surfaces. A method for the stabilization of 9-OH-E in polar solvents is proposed.
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Submitted on : Thursday, February 17, 2011 - 11:56:07 AM
Last modification on : Thursday, November 21, 2019 - 1:53:54 AM

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Pascal Formisyn, Félix Pautet, Canh Tran Minh, Jacques Bourgois. Determination of 9-hydroxyellipticine by redox colorimetry. Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 1992, 10 (6), pp.427-436. ⟨10.1016/0731-7085(92)80061-Q⟩. ⟨emse-00566875⟩

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