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Analysis of 9-Hydroxy Ellipticine by High-Performance Liquid Chromatography

Abstract : 9-hydroxyl derivative of ellipticine, compound of current interest known for its antitumor activity, shows a degradation in a reverse-phase column during High-Performance Liquid Chromatography analyses. In this paper, a chemical explanation of this phenomenon is proposed with the help of a degradation mechanism previously plubished, to understand the appearance of additionnal peaks corresponding to other products.
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Submitted on : Thursday, September 19, 2013 - 11:40:22 AM
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Jacques Bourgois, Pascal Formisyn, Anne-Marie Danna. Analysis of 9-Hydroxy Ellipticine by High-Performance Liquid Chromatography. Journal of Liquid Chromatography and Related Technologies, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 1995, Volume 18 (Issue 17), p. 3397-3408. ⟨10.1080/10826079508010458⟩. ⟨emse-00863614⟩



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